INDIRUBIN-3#-MONOXIME-5-SULP 1PC X 1MG

Biochem/physiol Actions

Cell permeable: no

Reversible: yes

Product competes with ATP.

Target IC₅₀: 5 nM, 7 nM, 80 nM, against Cdk1, Cdk5, and glycogen synthase kinase-3β (GSK-3β), respectively

Primary TargetCDK1

General description

A highly potent, reversible, and selective inhibitor of cyclin-dependent kinases 1 and 5 (IC₅₀ = 5 nM for CDK1; IC₅₀ = 7 nM for CDK5). Reported to act by competing with ATP for binding to the catalytic site of the kinase. Also acts as a potent inhibitor of glycogen synthase kinase-3β (GSK-3β; IC₅₀ = 80 nM).

A potent, reversible, and selective inhibitor of Cdk1 (IC₅₀ = 5 nM) and Cdk5 (IC₅₀ = 7 nM) and glycogen synthase kinase-3β (GSK-3β; IC₅₀ = 80 nM). The inhibition is competitive with respect to ATP.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Leclerc, S., et al. 2001. J. Biol. Chem.276, 251.

Packaging

1 mg in Plastic ampoule

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 4 months at -20°C.

Warning

Toxicity: Standard Handling (A)